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1

ChemInform Abstract: Process Research and Development of L-Alanyl-L-glutamine, a Component of Parenteral Nutrition.

Takahiro Sano, Toru Sugaya, Kunimi Inoue, Sho-ichi Mizutaki, Yasuyuki Ono, Masaji Kasai

Journal:

Year:

2000

File:

PDF, 28 KB

2000

2

Development of a Practical Synthetic Route of a PDE V Inhibitor KF31327

Fujino, Kenji, Takami, Hitoshi, Atsumi, Toshiyuki, Ogasa, Takehiro, Mohri, Shin-ichiro, Kasai, Masaji

Journal:

Organic Process Research & Development

Year:

2001

Language:

english

File:

PDF, 190 KB

english, 2001

3

Nickel-katalysierte Cyclodimerisation von Hexapentaenen: [4]Radialene und [5]Radialenone mit cumulierten Doppelbindungen

Prof. Dr. Masahiko Iyoda, Yoshiyuki Kuwatani, Prof. Dr. Masaji Oda, Prof. Dr. Yasushi Kai, Nobuko Kanehisa, Prof. Dr. Nobutami Kasai

Journal:

Angewandte Chemie

Year:

1990

File:

PDF, 345 KB

1990

4

Nickel-Catalyzed Cyclodimerization of Hexapentaenes: [4]Radialenes and [5]Radialenones with Cumulated Double Bonds

Prof. Dr. Masahiko Iyoda, Yoshiyuki Kuwatani, Prof. Dr. Masaji Oda, Prof. Dr. Yasushi Kai, Prof. Dr. Nobuko Kaneshisa, Nobutami Kasai

Journal:

Angewandte Chemie International Edition

Year:

1990

Language:

english

File:

PDF, 386 KB

english, 1990

5

ChemInform Abstract: Practical Synthesis of the High-Quality Antitumor Agent KW-2189 from Duocarmycin B2 Using a Facile One-Pot Synthesis of an Intermediate.

Masahiko Kinugawa, Satoru Nagamura, Akihiko Sakaguchi, Yoshiaki Masuda, Hiromitsu Saito, Takehiro Ogasa, Masaji Kasai

Journal:

Year:

1999

File:

PDF, 31 KB

1999

6

ChemInform Abstract: Synthetic Process Development of Antitumor Agent KT6587, an Indolocarbazole Alkaloid K252a Derivative.

Masahiko Kinugawa, Yukiteru Mimura, Yoshiaki Masuda, Chikara Murakata, Takehiro Ogasa, Masaji Kasai

Journal:

Year:

1999

File:

PDF, 32 KB

1999

7

ChemInform Abstract: An Efficient Synthesis of a New Class of DNA Intercalating Antitumor 7,10-Dihydroxy-6H-pyrazolo[4,5,1-de]acridin-6-ones.

Takashi Mimura, Nobuyuki Kato, Toru Sugaya, Masanori Ikuta, Sachiko Kato, Yukihiro Kuge, Shinji Tomioka, Masaji Kasai

Journal:

Year:

1999

File:

PDF, 29 KB

1999

8

ChemInform Abstract: Development of Large-Scale Synthetic Process for Antitumor Agent EO9

Masahiko Kinugawa, Hitoshi Arai, Takehiro Ogasa, Masaji Kasai

Journal:

Year:

1999

File:

PDF, 25 KB

1999

9

ChemInform Abstract: Development of a Practical Synthetic Route of a PDE V Inhibitor KF31327 (XIII).

Kenji Fujino, Hitoshi Takami, Toshiyuki Atsumi, Takehiro Ogasa, Shin-ichiro Mohri, Masaji Kasai

Journal:

Year:

2001

Language:

english

File:

PDF, 38 KB

english, 2001

10

Synthesis of mitomycin C labeled with mono-tritium at the C6 - methyl position

Yutaka Kanda, Shiro Akinaga, Masaji Kasai

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1990

Language:

english

File:

PDF, 165 KB

english, 1990

11

Synthesis of [C6-CH3-14C] and [C6-CH3-3H3]mitomycin C

Hitoshi Arai, Masaji Kasai

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1991

Language:

english

File:

PDF, 240 KB

english, 1991

12

The structure of tetronolide, the aglycone of antitumor antibiotic tetrocarcin

Noriaki Hirayama, Masaji Kasai, Kunikatsu Shirahata, Yuji Ohashi, Yoshio Sasada

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 127 KB

english, 1980

13

Absolute stereochemistry of (+)-trans-1,2-dihydroxyacenaphthene, a mammalian metabolite of acenaphthylene

Mitsuru Imuta, Masaji Kasai, Herman Ziffer

Journal:

Bioorganic Chemistry

Year:

1985

Language:

english

File:

PDF, 234 KB

english, 1985

14

Synthetic study on novel immunosuppressant KF20444

Iwao Chujo, Yoshiaki Masuda, Kenji Fujino, Sachiko Kato, Takehiro Ogasa, Shin-ichiro Mohri, Masaji Kasai

Journal:

Bioorganic & Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 294 KB

english, 2001

15

Comparison of uptake of mitomycin C and KW-2149 by murine P388 leukemia cells sensitive or resistant to mitomycin C

Eiji Kobayashi, Masami Okabe, Motomichi Kono, Hitoshi Arai, Masaji Kasai, Katsushige Gomi, Jeong-Hyung Lee, Makoto Inaba, Takashi Tsuruo

Journal:

Cancer Chemotherapy and Pharmacology

Year:

1993

Language:

english

File:

PDF, 586 KB

english, 1993

16

Design and Synthesis of Potent Antitumor 5,4‘-Diaminoflavone Derivatives Based on Metabolic Considerations

Akama, Tsutomu, Ishida, Hiroyuki, Shida, Yasushi, Kimura, Uichiro, Gomi, Katsushige, Saito, Hiromitsu, Fuse, Eiichi, Kobayashi, Satoshi, Yoda, Nobuyuki, Kasai, Masaji

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 203 KB

english, 1997

17

Novel 5-Aminoflavone Derivatives as Specific Antitumor Agents in Breast Cancer

Akama, Tsutomu, Shida, Yasushi, Sugaya, Toru, Ishida, Hiroyuki, Gomi, Katsushige, Kasai, Masaji

Journal:

Journal of Medicinal Chemistry

Year:

1996

Language:

english

File:

PDF, 354 KB

english, 1996

18

On the absolute stereochemistries of (-)-benzocyclohepten-3-ol, (-)-2,3,4,5-tetrahydro-1-benzoxepin-5-ol, and (-)-benzocycloocten-3-ol

Kasai, Masaji, Ziffer, Herman

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 537 KB

english, 1983

19

Microbially mediated enantioselective ester hydrolyses utilizing Rhizopus nigricans. A new method of assigning the absolute stereochemistry of acyclic 1-arylalkanols

Ziffer, Herman, Kawai, Kenichi, Kasai, Masaji, Imuta, Mitsuru, Froussios, Cleanthis

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 676 KB

english, 1983

20

Process Research and Development of l -Alanyl- l -glutamine, a Component of Parenteral Nutrition

Sano, Takahiro, Sugaya, Toru, Inoue, Kunimi, Mizutaki, Sho-ichi, Ono, Yasuyuki, Kasai, Masaji

Journal:

Organic Process Research & Development

Year:

2000

Language:

english

File:

PDF, 137 KB

english, 2000

21

Large Scale Synthesis of the High Quality Indoloquinone Antitumor Agent EO 9 via [Bis(trifluoroacetoxy)iodo]benzene Oxidation of 4-Aminoindole

Kinugawa, Masahiko, Masuda, Yoshiaki, Arai, Hitoshi, Nishikawa, Hiroshi, Ogasa, Takehiro, Tomioka, Shinji, Kasai, Masaji

Journal:

Year:

1996

File:

PDF, 317 KB

1996

22

Synthetic Process Development of Antitumor Agent KT6587, an Indolocarbazole Alkaloid K252a Derivative

Kinugawa, Masahiko, Mimura, Yukiteru, Masuda, Yoshiaki, Murakata, Chikara, Ogasa, Takehiro, Kasai, Masaji

Journal:

Organic Process Research & Development

Year:

1999

Language:

english

File:

PDF, 100 KB

english, 1999

23

Bioreductive activation of mitomycin C by DT-diaphorase

Siegel, David, Beall, Howard, Senekowitsch, Claudia, Kasai, Masaji, Arai, Hitoshi, Gibson, Neil W., Ross, David

Journal:

Year:

1992

Language:

english

File:

PDF, 1.22 MB

english, 1992

24

Synthesis of 9-epi-mitomycin B: the first inversion of the C-9 stereochemistry in mitomycin B

Kasai, Masaji, Kono, Motomichi, Shirahata, Kunikatsu

Journal:

Journal of Organic Chemistry

Year:

1989

Language:

english

File:

PDF, 481 KB

english, 1989

25

6-Demethyl-6-halo- and 6-Demethyl-6-thiomitomycins: Synthesis of Novel Mitomycin Derivatives Involving a Tandem Michael Addition/Retro-Mannich Reaction Sequence

Arai, Hitoshi, Kasai, Masaji

Journal:

Journal of Organic Chemistry

Year:

1994

Language:

english

File:

PDF, 1.10 MB

english, 1994

26

Synthesis and Antitumor Activity of Novel 6-Alkyl-6-demethylmitomycins

Arai, Hitoshi, Kanda, Yutaka, Ashizawa, Tadashi, Morimoto, Makoto, Gomi, Katsushige, Kono, Motomichi, Kasai, Masaji

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 679 KB

english, 1994

27

Facile nucleophilic cleavage of selenide with dimedone. Synthesis of novel 6-demethylmitomycins

Arai, Hitoshi, Kasai, Masaji

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 281 KB

english, 1993

28

Facile synthesis of the key intermediate of EO 9 via the formation of the indole skeleton using the Nenitzescu reaction

Kinugawa, Masahiko, Arai, Hitoshi, Nishikawa, Hiroshi, Sakaguchi, Akihiko, Ogasa, Takehiro, Tomioka, Shinji, Kasai, Masaji

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1995

Language:

english

File:

PDF, 266 KB

english, 1995

29

Ruthenium tetroxide catalyzed oxidations of aromatic and heteroaromatic rings

Kasai, Masaji, Ziffer, Herman

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 551 KB

english, 1983

30

Octaphenyl[4]radialene

Iyoda, Masahiko., Otani, Hiroyuki., Oda, Masaji., Kai, Yasushi., Baba, Yoshiko., Kasai, Nobutami.

Journal:

Journal of the American Chemical Society

Year:

1986

Language:

english

File:

PDF, 299 KB

english, 1986

31

First preparation of mitomycins specifically labeled with deuterium at the C6-methyl position

Kanda, Yutaka, Kasai, Masaji

Journal:

Journal of Organic Chemistry

Year:

1990

Language:

english

File:

PDF, 592 KB

english, 1990

32

Synthesis and Antitumor Activity of Various 6-Demethylmitomycins and 6-Demethyl-6-halomitomycins

Arai, Hitoshi, Ashizawa, Tadashi, Gomi, Katsushige, Kono, Motomichi, Saito, Hiromitsu, Kasai, Masaji

Journal:

Journal of Medicinal Chemistry

Year:

1995

Language:

english

File:

PDF, 1.22 MB

english, 1995

33

New potent mitomycin derivatives: synthesis and antitumor activity of 7,7-(ethylenedioxy)mitomycins

Kanda, Yutaka, Arai, Hitoshi, Ashizawa, Tadashi, Morimoto, Makoto, Kasai, Masaji

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 851 KB

english, 1992

34

Synthesis and Antitumor Activity of Novel Mitomycin Derivatives Containing Functional Groups at the C-6-Methyl Position

Arai, Hitoshi, Kanda, Yutaka, Ashizawa, Tadashi, Morimoto, Makoto, Gomi, Katsushige, Kono, Motomichi, Kasai, Masaji

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.21 MB

english, 1994

35

First synthesis of mitomycins completely labeled at the C-6-methyl by 13CH3 and CD3

Arai, Hitoshi, Kanda, Yutaka, Kasai, Masaji

Journal:

Journal of Organic Chemistry

Year:

1993

Language:

english

File:

PDF, 786 KB

english, 1993

36

Synthesis and biological evaluation of quinocarcin derivatives: thioalkyl-substituted quinones and hydroquinones

Saito, Hiromitsu, Hirata, Tadashi, Kasai, Masaji, Fujimoto, Kazuhisa, Ashizawa, Tadashi, Morimoto, Makoto, Sato, Akira

Journal:

Journal of Medicinal Chemistry

Year:

1991

Language:

english

File:

PDF, 1.04 MB

english, 1991

37

An efficient chemical conversion of mitomycin A to isomitomycin A

Kasai, Masaji, Kono, Motomichi, Ikeda, Shunichi, Yoda, Nobuyuki, Hirayama, Noriaki

Journal:

Journal of Organic Chemistry

Year:

1992

Language:

english

File:

PDF, 533 KB

english, 1992

38

Contamination of Dipeptide by Polymer Stabilizers Leached from Gloves and Packaging during Scale-up

Sano, Takahiro, Senzaki, Hirohiko, Sugaya, Toru, Kasai, Masaji

Journal:

Organic Process Research & Development

Year:

2000

Language:

english

File:

PDF, 112 KB

english, 2000

39

Practical Synthesis of the High-Quality Antitumor Agent KW-2189 from Duocarmycin B2 Using a Facile One-Pot Synthesis of an Intermediate

Kinugawa, Masahiko, Nagamura, Satoru, Sakaguchi, Akihiko, Masuda, Yoshiaki, Saito, Hiromitsu, Ogasa, Takehiro, Kasai, Masaji

Journal:

Organic Process Research & Development

Year:

1998

Language:

english

File:

PDF, 170 KB

english, 1998

40

On the relation between elution order and absolute stereochemistry of alkylarylcarbinols from a Pirkle column

Kasai, Masaji, Froussios, Cleanthis, Ziffer, Herman

Journal:

Journal of Organic Chemistry

Year:

1983

Language:

english

File:

PDF, 757 KB

english, 1983

41

Process Improvement in the Production of a Pharmaceutical Intermediate Using a Reaction Calorimeter for Studies on the Reaction Kinetics of Amination of a Bromopropyl Compound

Sano, Takahiro, Sugaya, Toru, Kasai, Masaji

Journal:

Organic Process Research & Development

Year:

1998

Language:

english

File:

PDF, 136 KB

english, 1998

42

An unusual replacement of a methylene moiety by a phenylseleno group. Synthesis of mitomycin C labelled at C-6 by 13CH3 and C2H3

Kasai, Masaji, Arai, Hitoshi, Kanda, Yutaka

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1991

Language:

english

File:

PDF, 236 KB

english, 1991

43

Synthesis and properties of 4,4?-bi(cyclopentene)-3,3?,5,5?-tetraone

Kasai, Masaji, Funamizu, Makoto, Oda, Masaji, Kitahara, Yoshio

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1977

Language:

english

File:

PDF, 252 KB

english, 1977

44

Novel cyclization of a copper carbenoid: the first synthesis of a [5]radialene (pentamethylenecyclopentane) derivative

Lyoda, Masahiko, Otani, Hiroyuki, Oda, Masaji, Kai, Yasushi, Baba, Yoshiko, Kasai, Nobutami

Journal:

Journal of the Chemical Society Chemical Communications

Year:

1986

Language:

english

File:

PDF, 217 KB

english, 1986

45

Preparation of chiral allylic alcohols using Rhizopus nigricans . Use of the Harada–Nakanishi exciton chirality method for verifying configurational assignments of allylic alcohols

Ito, Satoru, Kasai, Masaji, Ziffer, Herman, Sllverton, J. V.

Journal:

Canadian Journal of Chemistry

Year:

1987

Language:

english

File:

PDF, 591 KB

english, 1987

46

Enantioselective ester hydrolyses using Rhizopus nigricans : stereoselective synthesis and absolute stereochemistry of (−)- cis - and (−)- trans -1-hydroxy-4-methyl-1,2,3,4-tetrahydronaphthalene

Kasai, Masaji, Ziffer, Herman, Silverton, J. V.

Journal:

Canadian Journal of Chemistry

Year:

1985

Language:

english

File:

PDF, 332 KB

english, 1985

47

Enantioselective ester hydrolyses employing Rhizopus nigricans. A method of preparing and assigning the absolute stereochemistry of cyclic alcohols

Kasai, Masaji, Kawai, Kenichi, Imuta, Mitsuru, Ziffer, Herman

Journal:

Journal of Organic Chemistry

Year:

1984

Language:

english

File:

PDF, 632 KB

english, 1984

48

Improved Synthesis of Mitomycin G

Kono, Motomichi, Kasai, Masaji, Shirahata, Kunikatsu

Journal:

Synthetic Communications

Year:

1989

Language:

english

File:

PDF, 208 KB

english, 1989

49

Studies on the Chemistry of Mitomycins

Kasai, Masaji, Kono, Motomichi

Journal:

Year:

1992

File:

PDF, 1023 KB

1992

50

Synthesis of a 6 H -Pyrazolo[4,5,1- de ]acridin-6-one Derivative: A Useful Intermediate of Antitumour Agents

Sugaya, Toru, Mimura, Yukiteru, Kato, Nobuyuki, Ikuta, Masanori, Mimura, Takashi, Kasai, Masaji, Tomioka, Shinji

Journal:

Year:

1994

File:

PDF, 306 KB

1994